There are many different factors that affect the effect of medications. One of the most important and significant is considered to be the half-life of the compounds. Using medical terminology, the half-life is the time from the moment of consumption to the excretion from the body, during which half of the active substance decomposes.
Here it is necessary to clarify the following: we are not talking about half the time interval while the compound acts in the body, but about the metabolism of 50 percent of the total substance in the body.
For example, if you ingest a substance with a half-life of eight hours in an amount of 100 mg, after this period of time only 50 mg of the active form will be contained in the blood, after another eight hours – 25 mg. It will take more than one such period for the substance to be completely removed from the body.
Recognation the half-life can prevent falls and spikes in steroid levels in the body.
Long half-life – when research on steroids is just beginning, it is difficult to create synthetic analogues, which is difficult because of the half-life. Because steroids produced directly by the body are toxic, their half-lives are very short.
For example, the half-life of conventional testosterone is about two minutes, less than an hour from injection to complete release. The liver is involved in the metabolism of steroids, so only a small part enters the blood in pure form.
The only way out of this situation seems to be the use of constant injections of testosterone. However, this is not the most convenient and pleasant procedure, which is why scientists have begun to develop a theory to prolong the life of testosterone and other steroid-type hormones in the body.
They proposed two of the most famous methods. As a result, the pharmaceutical industry approved them.
This process is the addition of an additional carbon atom to the steroid chain at the seventeenth position. This atom has a striking effect on the metabolic action of the seventeenth keto group, including it in the molecule in the alpha position.
This method increases the half-life from minutes to hours, but at the same time does not allow interaction with androgen receptors.
This method is best suited for oral medications: while the liver makes an effort to process the modified hormone, a significant portion of it enters the bloodstream without being altered. This does not pass without leaving a trace on the body: the negative effect is associated with a toxic effect that affects the liver.
Esterification of injectable steroids
This is the process of binding to steroid molecules in the seventeenth beta position of a fatty acid. The main task of this type of modification is to protect the hydroxyl group in the seventeenth position.
Because such esters are extremely complex, a sharp rise in the level of the drug in the blood becomes difficult and, moreover, the body can gradually consume such a substance. It turns out that the duration of action of the substance increases to several weeks and this helps to maintain a given level of the drug in the body, avoiding spikes.
Stages of disintegration of injectable steroids:
the first stage is the release of hormones from the so-called depot, ie the injection site. It usually takes a few days (for most medicines);
Тhe second stage – the half-life of the substance occurs in the blood.
The first stage is more related to self-interest, while the second will be beneficial for each user.